Complementary sleep support
Magnesium supports GABA activity and muscle relaxation, while melatonin regulates sleep timing. Together they address different aspects of sleep.
Safe and effective combination for sleep support.
Take both 30-60 minutes before bed
Complementary sleep support. Safe and effective combination for sleep support.
Take both 30-60 minutes before bed
This interaction is rated “Synergy” by Formulate. Magnesium supports GABA activity and muscle relaxation, while melatonin regulates sleep timing. Together they address different aspects of sleep.
Studies from our registry that mention both magnesium and melatonin. Each links to the primary source and the other Formulate pages citing it.
Both substances · 2012
The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial
Abbasi B, Kimiagar M, Sadeghniiat K, et al. · Journal of Research in Medical Sciences
8-week RCT in elderly with insomnia: 500mg/day magnesium significantly improved subjective insomnia score, sleep efficiency, sleep onset latency, and serum melatonin concentration.
Mentions magnesium · 2018
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia
Pouteau et al. · PLOS ONE
Mg+B6 combination outperformed Mg alone for stress score reduction in adults with low baseline magnesium.
Mentions magnesium · 2018
The role of magnesium in neurological disorders
Kirkland AE, Sarlo GL, Holton KF · Nutrients
Reviews mechanisms and clinical evidence for magnesium's role in migraine prophylaxis, stress, anxiety, and depression — with strongest RCT support for migraine prevention at 400–600mg/day.
Mentions magnesium · 2016
Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized double-blind placebo-controlled trials
Zhang X, Li Y, Del Gobbo LC, et al. · Hypertension
Meta-analysis of 34 trials (n=2,028) found magnesium supplementation at a median dose of 368mg/day for 3 months significantly reduced systolic BP by 2.00 mmHg and diastolic BP by 1.78 mmHg.
Mentions magnesium · 2016
Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults
Liu et al. · Journal of Alzheimer's Disease
Magnesium L-threonate (Magtein) improved cognitive ability in older adults with cognitive concerns over 12 weeks.
Mentions melatonin · 2013
Meta-analysis: melatonin for the treatment of primary sleep disorders
Ferracioli-Oda E, Qawasmi A, Bloch MH · PLOS ONE
Meta-analysis of 19 RCTs (n=1,683) found melatonin reduced sleep-onset latency by ~7 minutes, increased total sleep time by ~8 minutes, and improved overall sleep quality — small but consistent effect across populations.
Guide
Magnesium Glycinate vs Citrate vs Oxide: Which Form Actually Absorbs?
Glycinate (80% absorbed) vs citrate (50%) vs oxide (4%) — with elemental-dose math, side effects, and picks for sleep, constipation, and cognition.
Roundup
Best Magnesium Supplements 2026, Ranked by Clinical Evidence
Learn which magnesium form actually matches your goal. We scored glycinate, threonate, and citrate on absorption, dose accuracy, and third-party testing.
Guide
8 Signs of Magnesium Deficiency – 2026 Guide
Muscle cramps, twitching eyelids, and poor sleep may signal low magnesium. Learn all 8 signs, why standard blood tests miss it, and how to fix it.
Guide
Electrolytes Guide 2026: Evidence-Based Sodium, Potassium & Magnesium
Discover who actually needs electrolyte supplements, the real science on sodium, and a DIY fix for keto flu symptoms — for about 15 cents a day.
Other interactions to know
PPIs can cause hypomagnesemia
High calcium can impair magnesium absorption
Melatonin may affect blood clotting
Magnesium may enhance BP lowering effect
PPIs impair magnesium absorption
NSAIDs may reduce magnesium levels
Both cause sedation - enhanced drowsiness
Melatonin may enhance SSRI side effects
Check your full stack in the free interaction checker.
The free checker lets you add any combination of supplements and medications at once. The free web app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
Last medically reviewed: