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diphenhydramine and melatonin

Both cause sedation - enhanced drowsiness

What's happening

Benadryl (diphenhydramine) is an anticholinergic sedative. Combined with melatonin, may cause excessive drowsiness, next-day grogginess, cognitive impairment.

Recommendation

Choose one or the other. If combining, use minimal doses.

Timing

Be aware of enhanced sedation; don't drive

Sources

  • — Sleep Medicine Reviews
  • — PMID: 20493772

Frequently Asked Questions

Can I take diphenhydramine and melatonin together?

Both cause sedation - enhanced drowsiness. Choose one or the other. If combining, use minimal doses.

How should I time diphenhydramine and melatonin?

Be aware of enhanced sedation; don't drive

Is this interaction dangerous?

This interaction is rated “Caution” by Formulate. Benadryl (diphenhydramine) is an anticholinergic sedative. Combined with melatonin, may cause excessive drowsiness, next-day grogginess, cognitive impairment.

Want to check your whole stack?

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.