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melatonin and ssri

Melatonin may enhance SSRI side effects

What's happening

Some SSRIs (especially fluvoxamine) inhibit CYP1A2, which metabolizes melatonin. This can increase melatonin blood levels, causing excessive sedation.

Recommendation

Use lower melatonin doses (0.3-0.5mg) with SSRIs. Monitor for oversedation.

Timing

Start with lower melatonin doses

Sources

  • — Clinical Pharmacology & Therapeutics
  • — PMID: 11502890

Frequently Asked Questions

Can I take melatonin and ssri together?

Melatonin may enhance SSRI side effects. Use lower melatonin doses (0.3-0.5mg) with SSRIs. Monitor for oversedation.

How should I time melatonin and ssri?

Start with lower melatonin doses

Is this interaction dangerous?

This interaction is rated “Caution” by Formulate. Some SSRIs (especially fluvoxamine) inhibit CYP1A2, which metabolizes melatonin. This can increase melatonin blood levels, causing excessive sedation.

Want to check your whole stack?

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.