Skip to main content

sam-e and ssri

SAM-e with SSRIs: Serotonin syndrome risk

What's happening

SAM-e increases serotonin synthesis and activity. Combined with SSRIs, increases serotonin syndrome risk. Some psychiatrists do combine carefully under supervision, but not without monitoring.

Recommendation

Do not combine without psychiatric supervision. Risk of serotonin syndrome.

Timing

Requires medical supervision if combined

Sources

  • — American Journal of Psychiatry
  • — PMID: 14636358

Frequently Asked Questions

Can I take sam-e and ssri together?

SAM-e with SSRIs: Serotonin syndrome risk. Do not combine without psychiatric supervision. Risk of serotonin syndrome.

How should I time sam-e and ssri?

Requires medical supervision if combined

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. SAM-e increases serotonin synthesis and activity. Combined with SSRIs, increases serotonin syndrome risk. Some psychiatrists do combine carefully under supervision, but not without monitoring.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

Open the checkerGet the desktop app

Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.