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5-htp and ssri

Risk of serotonin syndrome

What's happening

5-HTP is a direct serotonin precursor. Combined with SSRIs (which prevent serotonin reuptake), can cause dangerous serotonin excess. Serotonin syndrome symptoms: agitation, hyperthermia, tremor, rigid muscles, potentially fatal.

Recommendation

Do NOT combine 5-HTP with any SSRI, SNRI, or MAOI. Life-threatening interaction.

Timing

Never combine - no safe timing

Sources

  • — FDA
  • — Journal of Clinical Psychiatry
  • — PMID: 11775047

Frequently Asked Questions

Can I take 5-htp and ssri together?

Risk of serotonin syndrome. Do NOT combine 5-HTP with any SSRI, SNRI, or MAOI. Life-threatening interaction.

How should I time 5-htp and ssri?

Never combine - no safe timing

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. 5-HTP is a direct serotonin precursor. Combined with SSRIs (which prevent serotonin reuptake), can cause dangerous serotonin excess. Serotonin syndrome symptoms: agitation, hyperthermia, tremor, rigid muscles, potentially fatal.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.