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5-htp and tryptophan

Both increase serotonin - risk of excess

What's happening

Tryptophan and 5-HTP both increase serotonin levels. Taking together significantly increases risk of serotonin syndrome.

Recommendation

Do not combine - choose one or the other.

Timing

Do not take together

Sources

  • — Psychopharmacology

Frequently Asked Questions

Can I take 5-htp and tryptophan together?

Both increase serotonin - risk of excess. Do not combine - choose one or the other.

How should I time 5-htp and tryptophan?

Do not take together

Is this interaction dangerous?

This interaction is rated “Warning” by Formulate. Tryptophan and 5-HTP both increase serotonin levels. Taking together significantly increases risk of serotonin syndrome.

Learn more about each substance

Other interactions to know

More interactions involving 5-htp or tryptophan

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.

Last medically reviewed: