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5-htp and tryptophan

Both increase serotonin - risk of excess

What's happening

Tryptophan and 5-HTP both increase serotonin levels. Taking together significantly increases risk of serotonin syndrome.

Recommendation

Do not combine - choose one or the other.

Timing

Do not take together

Sources

  • — Psychopharmacology

Frequently Asked Questions

Can I take 5-htp and tryptophan together?

Both increase serotonin - risk of excess. Do not combine - choose one or the other.

How should I time 5-htp and tryptophan?

Do not take together

Is this interaction dangerous?

This interaction is rated “Warning” by Formulate. Tryptophan and 5-HTP both increase serotonin levels. Taking together significantly increases risk of serotonin syndrome.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.