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5-htp and tyrosine

Tyrosine and 5-HTP compete for brain uptake

What's happening

Both amino acids use the same transporter to cross the blood-brain barrier. Taking together may reduce effectiveness of both.

Recommendation

Take at different times of day for best effect.

Timing

Separate by 4+ hours; tyrosine in morning, 5-HTP in evening

Sources

  • — Journal of Neural Transmission

Frequently Asked Questions

Can I take 5-htp and tyrosine together?

Tyrosine and 5-HTP compete for brain uptake. Take at different times of day for best effect.

How should I time 5-htp and tyrosine?

Separate by 4+ hours; tyrosine in morning, 5-HTP in evening

Is this interaction dangerous?

This interaction is rated “Warning” by Formulate. Both amino acids use the same transporter to cross the blood-brain barrier. Taking together may reduce effectiveness of both.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.