Tyrosine and 5-HTP compete for brain uptake
Both amino acids use the same transporter to cross the blood-brain barrier. Taking together may reduce effectiveness of both.
Take at different times of day for best effect.
Separate by 4+ hours; tyrosine in morning, 5-HTP in evening
Tyrosine and 5-HTP compete for brain uptake. Take at different times of day for best effect.
Separate by 4+ hours; tyrosine in morning, 5-HTP in evening
This interaction is rated “Warning” by Formulate. Both amino acids use the same transporter to cross the blood-brain barrier. Taking together may reduce effectiveness of both.
Other interactions to know
Risk of serotonin syndrome
Tyrosine can cause hypertensive crisis with MAOIs
Both increase serotonin - risk of excess
BCAAs may reduce tyrosine brain uptake
Check your full stack in the free interaction checker.
The free checker lets you add any combination of supplements and medications at once. The free web app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
Last medically reviewed: