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maoi and tyrosine

Tyrosine can cause hypertensive crisis with MAOIs

What's happening

Tyrosine is a precursor to dopamine, norepinephrine, and epinephrine. MAOIs prevent breakdown of these neurotransmitters. Combining can cause dangerous catecholamine surge with severe hypertension, potentially stroke.

Recommendation

Do NOT take tyrosine with MAOIs.

Timing

Avoid combination

Sources

  • — Pharmacopsychiatry
  • — PMID: 2399766

Frequently Asked Questions

Can I take maoi and tyrosine together?

Tyrosine can cause hypertensive crisis with MAOIs. Do NOT take tyrosine with MAOIs.

How should I time maoi and tyrosine?

Avoid combination

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. Tyrosine is a precursor to dopamine, norepinephrine, and epinephrine. MAOIs prevent breakdown of these neurotransmitters. Combining can cause dangerous catecholamine surge with severe hypertension, potentially stroke.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.