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Amino Acid

L-Tryptophan

Also known as: TRP, Tryptophan

B
Evidence

Essential amino acid precursor to serotonin and melatonin. Supports mood and sleep through 5-HTP pathway.

Primary uses

  • Sleep
  • Mood support
  • Serotonin production

How it works

  • Converted to 5-HTP then serotonin
  • Serotonin converted to melatonin
  • Rate-limited by tryptophan hydroxylase

Dosage

Typical range
500-2000 mg daily
Timing
Evening for sleep; any for mood
With food
Small carb helps absorption
Duration
Safe long-term
Special populations
Sleep issues, mood support

Forms

  • Capsules

Safety

Common side effects

  • Drowsiness
  • Nausea

Contraindications

  • MAOIs
  • Use caution with SSRIs

Known interactions

Evidence notes

Serotonin and melatonin precursor

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.