Amino Acid
L-Histidine
Also known as: Histidine, His, L-Histidine HCl, L-Histidine Hydrochloride
L-Histidine is an essential amino acid precursor to histamine and carnosine, involved in immune function, wound healing, and neurotransmission. Evidence for isolated supplementation in healthy adults is limited, though histidine is necessary for normal physiological function.
Primary uses
- Histamine precursor
- Carnosine synthesis
- Immune support
- Antioxidant (via carnosine)
- Amino acid supplementation
- Histamine production
- Protein synthesis
- Immune function support
How it works
- Decarboxylated to histamine
- Combines with beta-alanine to form carnosine
- Metal ion chelation
- Important for hemoglobin structure
Dosage
- Typical range
- 500-2000 mg daily
- Timing
- With meals
- With food
- With or without
- Duration
- Safe long-term
- Special populations
- Those with histamine issues use caution
Forms
- Capsule
- Powder
- Hydrochloride salt (HCl)· 70/100
Safety
Common side effects
- Well tolerated
Contraindications
- Severe histamine intolerance
Evidence notes
Established physiological roles in multiple systems
Grade B: Some human trials support key claims; further confirmation needed.
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