Ashwagandha may enhance SSRI effects
Ashwagandha has mild serotonergic and GABAergic activity. Adding it to an SSRI is not known to cause serotonin syndrome but may potentiate sedation, dizziness, or mood changes, especially during dose changes.
If on an SSRI, introduce ashwagandha at a low dose (300mg) and monitor. Discuss with your prescriber before adding.
If combined, take at different times of day to separate peak effects
Ashwagandha may enhance SSRI effects. If on an SSRI, introduce ashwagandha at a low dose (300mg) and monitor. Discuss with your prescriber before adding.
If combined, take at different times of day to separate peak effects
This interaction is rated “Caution” by Formulate. Ashwagandha has mild serotonergic and GABAergic activity. Adding it to an SSRI is not known to cause serotonin syndrome but may potentiate sedation, dizziness, or mood changes, especially during dose changes.
The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.