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Adaptogen

Withania somnifera Extract (Whole Plant)

Also known as: Ashwagandha, Indian Ginseng, Winter Cherry, Withanolides extract

B
Evidence

Withania somnifera (ashwagandha) is a traditional Ayurvedic herb standardized to withanolides, the active compounds responsible for its adaptogenic effects. Multiple clinical trials support its use for stress reduction, cortisol modulation, and anxiety management.

Primary uses

  • Stress and anxiety reduction
  • Cortisol regulation
  • Sleep quality improvement
  • Cognitive function support
  • Mood enhancement
  • Physical stress resilience

How it works

  • Withanolides modulate GABA and serotonin signaling
  • Reduces cortisol and stress biomarkers
  • Antioxidant and anti-inflammatory effects
  • Supports HPA axis (hypothalamic-pituitary-adrenal) function

Dosage

Typical range
300-600 mg daily (standardized to 5-9% withanolides)
Timing
Once or twice daily with meals
With food
With food may improve absorption and reduce gastrointestinal upset
Duration
Consistent use for 4-8 weeks recommended for full adaptogenic benefits; long-term use is generally safe
Special populations
Pregnant/nursing women should consult healthcare provider; those on sedatives may experience additive effects

Forms

  • Extract (whole plant)· 70/100
  • Standardized powder· 70/100
  • Tablet· 70/100
  • Capsule· 70/100
  • Liquid extract· 70/100

Safety

Common side effects

  • Mild gastrointestinal upset
  • Drowsiness at higher doses
  • Headache (rare)
  • Stomach upset if taken on empty stomach

Contraindications

  • Pregnancy and breastfeeding (use with caution)
  • Concurrent use with sedating medications
  • Nightshade sensitivity (Withania is in Solanaceae family)
  • Thyroid disorders (may have minor thyroid effects)

Evidence notes

Multiple randomized controlled trials demonstrate efficacy for anxiety, stress, and cortisol reduction. Well-established traditional use with consistent clinical evidence. 9% withanolide standardization is a clinically relevant dose.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.