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Adaptogen

Withania somnifera Extract (Whole Plant)

Also known as: Ashwagandha, Indian Ginseng, Winter Cherry, Withanolides extract

B
Evidence

Withania somnifera (ashwagandha) is a traditional Ayurvedic herb standardized to withanolides, the active compounds responsible for its adaptogenic effects. Multiple clinical trials support its use for stress reduction, cortisol modulation, and anxiety management.

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Primary uses

  • Stress and anxiety reduction
  • Cortisol regulation
  • Sleep quality improvement
  • Cognitive function support
  • Mood enhancement
  • Physical stress resilience

How it works

  • Withanolides modulate GABA and serotonin signaling
  • Reduces cortisol and stress biomarkers
  • Antioxidant and anti-inflammatory effects
  • Supports HPA axis (hypothalamic-pituitary-adrenal) function

Dosage

Typical range
300-600 mg daily (standardized to 5-9% withanolides)
Timing
Once or twice daily with meals
With food
With food may improve absorption and reduce gastrointestinal upset
Duration
Consistent use for 4-8 weeks recommended for full adaptogenic benefits; long-term use is generally safe
Special populations
Pregnant/nursing women should consult healthcare provider; those on sedatives may experience additive effects

Forms

  • Extract (whole plant)· 70/100
  • Standardized powder· 70/100
  • Tablet· 70/100
  • Capsule· 70/100
  • Liquid extract· 70/100

Safety

Common side effects

  • Mild gastrointestinal upset
  • Drowsiness at higher doses
  • Headache (rare)
  • Stomach upset if taken on empty stomach

Contraindications

  • Pregnancy and breastfeeding (use with caution)
  • Concurrent use with sedating medications
  • Nightshade sensitivity (Withania is in Solanaceae family)
  • Thyroid disorders (may have minor thyroid effects)

Products containing Withania somnifera Extract (Whole Plant)

Top-scoring supplements in our catalog that list Withania somnifera Extract (Whole Plant) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Nootropics Depot
Shoden® Ashwagandha Capsules
96
Nutricost
Ashwagandha Root Capsules
95
Transparent Labs
KSM-66 Ashwagandha Supplement
95
Nootropics Depot
Ashwagandha Extract Powder
95
See all products →

Evidence notes

Multiple randomized controlled trials demonstrate efficacy for anxiety, stress, and cortisol reduction. Well-established traditional use with consistent clinical evidence. 9% withanolide standardization is a clinically relevant dose.

Grade B: Some human trials support key claims; further confirmation needed.

Cited research for Withania somnifera Extract (Whole Plant)

Clinical studies referenced across Formulate guides that mention withania somnifera extract (whole plant). Each links to the full study page with PubMed source + the guides that cite it.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.