Rhodiola may have mild MAOI effects
Rhodiola rosea may have mild MAO-inhibiting properties. Combined with SSRIs, theoretical risk of serotonin syndrome, though clinical reports are limited.
Use cautiously with SSRIs. Start with low doses and monitor mood.
Start with low doses; watch for agitation, anxiety
Rhodiola may have mild MAOI effects. Use cautiously with SSRIs. Start with low doses and monitor mood.
Start with low doses; watch for agitation, anxiety
This interaction is rated “Caution” by Formulate. Rhodiola rosea may have mild MAO-inhibiting properties. Combined with SSRIs, theoretical risk of serotonin syndrome, though clinical reports are limited.
Studies from our registry that mention both rhodiola and ssri. Each links to the primary source and the other Formulate pages citing it.
Both substances · 2015
Rhodiola rosea versus sertraline for major depressive disorder: a randomized placebo-controlled trial
Mao JJ, Xie SX, Zee J, et al. · Phytomedicine
12-week three-arm RCT (n=57) found rhodiola produced smaller antidepressant effect than sertraline but with significantly fewer adverse events, supporting it as an option for milder depression.
Mentions ssri · 2024
St. John's Wort — StatPearls
Primary literature · Monograph
Identifies SSRIs (sertraline, paroxetine, fluoxetine, citalopram) as high-concern co-administration targets due to serotonin syndrome risk. Typical SJW doses implicated: 600-900 mg/day standardized extract. Typical SSRI doses in case reports: 20-75 mg/day.
Mentions rhodiola · 2011
The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials
Hung SK, Perry R, Ernst E · Phytomedicine
Systematic review of 11 RCTs found modest but consistent evidence for rhodiola in physical and mental fatigue, with less consistent data for chronic depression and anxiety.
Other interactions to know
Combining St John's wort with any SSRI risks serotonin syndrome — a potentially fatal hyperserotonergic state.
Risk of serotonin syndrome
SAM-e with SSRIs: Serotonin syndrome risk
Melatonin may enhance SSRI side effects
Ashwagandha may enhance SSRI effects
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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