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Mood Support

SAM-e

Also known as: S-Adenosyl-L-methionine, Ademetionine

A
Evidence

Universal methyl donor supporting mood, joints, and liver. Comparable to antidepressants.

Primary uses

  • Mood support
  • Joint health
  • Liver support
  • Methylation

How it works

  • Major methyl donor
  • Supports neurotransmitter synthesis
  • Cartilage and liver protection

Dosage

Typical range
400-1600mg daily
Timing
Morning empty stomach
With food
No
Duration
2-4 weeks for mood effects
Special populations
Depression, joints, liver

Forms

  • Enteric-coated tablet

Safety

Common side effects

  • GI upset
  • Anxiety
  • Insomnia
  • Headache

Contraindications

  • Bipolar
  • SSRIs without supervision

Known interactions

Evidence notes

Strong evidence for depression

Grade A: Multiple well-designed human trials support the main claims.

Related in Mood Support

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.