Mood Support
SAM-e
Also known as: S-Adenosyl-L-methionine, Ademetionine
Universal methyl donor supporting mood, joints, and liver. Comparable to antidepressants.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Mood support
- Joint health
- Liver support
- Methylation
How it works
- Major methyl donor
- Supports neurotransmitter synthesis
- Cartilage and liver protection
Dosage
- Typical range
- 400-1600mg daily
- Timing
- Morning empty stomach
- With food
- No
- Duration
- 2-4 weeks for mood effects
- Special populations
- Depression, joints, liver
Forms
- Enteric-coated tablet
Safety
Common side effects
- GI upset
- Anxiety
- Insomnia
- Headache
Contraindications
- Bipolar
- SSRIs without supervision
Known interactions
Evidence notes
Strong evidence for depression
Grade A: Multiple well-designed human trials support the main claims.
Related in Mood Support
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.