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antacids and magnesium

PPIs impair magnesium absorption

What's happening

Long-term PPI use associated with hypomagnesemia (low magnesium). FDA issued warning in 2011. Can cause muscle cramps, arrhythmias, seizures. Risk increases with duration.

Recommendation

Monitor magnesium levels on long-term PPIs. Supplement if low.

Timing

Take magnesium supplements at different time than PPI

Sources

  • — FDA Drug Safety Communication 2011
  • — PMID: 21388145

Frequently Asked Questions

Can I take antacids and magnesium together?

PPIs impair magnesium absorption. Monitor magnesium levels on long-term PPIs. Supplement if low.

How should I time antacids and magnesium?

Take magnesium supplements at different time than PPI

Is this interaction dangerous?

This interaction is rated “Caution” by Formulate. Long-term PPI use associated with hypomagnesemia (low magnesium). FDA issued warning in 2011. Can cause muscle cramps, arrhythmias, seizures. Risk increases with duration.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.