PPIs can cause hypomagnesemia
The FDA issued a safety warning in 2011: PPI use >1 year is associated with low serum magnesium, sometimes severe enough to require hospitalization. Mechanism involves reduced intestinal absorption.
Monitor magnesium levels annually on long-term PPIs. Supplement with 200-400mg magnesium glycinate if levels are low.
Take magnesium 2+ hours away from PPI dose
PPIs can cause hypomagnesemia. Monitor magnesium levels annually on long-term PPIs. Supplement with 200-400mg magnesium glycinate if levels are low.
Take magnesium 2+ hours away from PPI dose
This interaction is rated “Warning” by Formulate. The FDA issued a safety warning in 2011: PPI use >1 year is associated with low serum magnesium, sometimes severe enough to require hospitalization. Mechanism involves reduced intestinal absorption.
Studies from our registry that mention magnesium or ppi. Each links to the primary source and the other Formulate pages citing it.
Mentions magnesium · 2018
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia
Pouteau et al. · PLOS ONE
Mg+B6 combination outperformed Mg alone for stress score reduction in adults with low baseline magnesium.
Mentions magnesium · 2018
The role of magnesium in neurological disorders
Kirkland AE, Sarlo GL, Holton KF · Nutrients
Reviews mechanisms and clinical evidence for magnesium's role in migraine prophylaxis, stress, anxiety, and depression — with strongest RCT support for migraine prevention at 400–600mg/day.
Mentions magnesium · 2016
Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized double-blind placebo-controlled trials
Zhang X, Li Y, Del Gobbo LC, et al. · Hypertension
Meta-analysis of 34 trials (n=2,028) found magnesium supplementation at a median dose of 368mg/day for 3 months significantly reduced systolic BP by 2.00 mmHg and diastolic BP by 1.78 mmHg.
Mentions magnesium · 2016
Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults
Liu et al. · Journal of Alzheimer's Disease
Magnesium L-threonate (Magtein) improved cognitive ability in older adults with cognitive concerns over 12 weeks.
Mentions magnesium · 2012
The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial
Abbasi B, Kimiagar M, Sadeghniiat K, et al. · Journal of Research in Medical Sciences
8-week RCT in elderly with insomnia: 500mg/day magnesium significantly improved subjective insomnia score, sleep efficiency, sleep onset latency, and serum melatonin concentration.
Mentions magnesium · 2012
Suboptimal magnesium status in the United States
Rosanoff et al. · Nutrition Reviews
Estimated ~50% of Americans consume less than the EAR for magnesium.
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8 Signs of Magnesium Deficiency – 2026 Guide
Muscle cramps, twitching eyelids, and poor sleep may signal low magnesium. Learn all 8 signs, why standard blood tests miss it, and how to fix it.
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Electrolytes Guide 2026: Evidence-Based Sodium, Potassium & Magnesium
Discover who actually needs electrolyte supplements, the real science on sodium, and a DIY fix for keto flu symptoms — for about 15 cents a day.
Other interactions to know
Long-term PPI use reduces B12 absorption
High calcium can impair magnesium absorption
Magnesium may enhance BP lowering effect
PPIs impair magnesium absorption
NSAIDs may reduce magnesium levels
Magnesium may reduce thyroid med absorption
PPIs reduce calcium carbonate absorption
PPIs reduce non-heme iron absorption
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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