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magnesium and ppi

PPIs can cause hypomagnesemia

What's happening

The FDA issued a safety warning in 2011: PPI use >1 year is associated with low serum magnesium, sometimes severe enough to require hospitalization. Mechanism involves reduced intestinal absorption.

Recommendation

Monitor magnesium levels annually on long-term PPIs. Supplement with 200-400mg magnesium glycinate if levels are low.

Timing

Take magnesium 2+ hours away from PPI dose

Sources

  • — FDA Drug Safety Communication 2011
  • — PMID: 22109896

Frequently Asked Questions

Can I take magnesium and ppi together?

PPIs can cause hypomagnesemia. Monitor magnesium levels annually on long-term PPIs. Supplement with 200-400mg magnesium glycinate if levels are low.

How should I time magnesium and ppi?

Take magnesium 2+ hours away from PPI dose

Is this interaction dangerous?

This interaction is rated “Warning” by Formulate. The FDA issued a safety warning in 2011: PPI use >1 year is associated with low serum magnesium, sometimes severe enough to require hospitalization. Mechanism involves reduced intestinal absorption.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.