Long-term PPI use reduces B12 absorption
Proton pump inhibitors (omeprazole, esomeprazole, etc.) suppress stomach acid needed to release B12 from food proteins. Use >2 years is associated with a ~65% increase in B12 deficiency risk.
If on long-term PPIs, supplement with methylcobalamin (1000mcg) or sublingual B12 which bypasses the need for gastric acid.
Take B12 supplement separately; form matters more than timing
Long-term PPI use reduces B12 absorption. If on long-term PPIs, supplement with methylcobalamin (1000mcg) or sublingual B12 which bypasses the need for gastric acid.
Take B12 supplement separately; form matters more than timing
This interaction is rated “Warning” by Formulate. Proton pump inhibitors (omeprazole, esomeprazole, etc.) suppress stomach acid needed to release B12 from food proteins. Use >2 years is associated with a ~65% increase in B12 deficiency risk.
The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.