PPIs reduce non-heme iron absorption
Gastric acid is required to reduce ferric iron to the absorbable ferrous form. PPI use can worsen iron-deficiency anemia, especially in people with marginal iron status.
If iron-deficient on PPIs, take iron bisglycinate (requires less acid) with vitamin C to enhance absorption. Consider checking ferritin.
Take iron 2+ hours away from PPI with 500mg vitamin C
PPIs reduce non-heme iron absorption. If iron-deficient on PPIs, take iron bisglycinate (requires less acid) with vitamin C to enhance absorption. Consider checking ferritin.
Take iron 2+ hours away from PPI with 500mg vitamin C
This interaction is rated “Caution” by Formulate. Gastric acid is required to reduce ferric iron to the absorbable ferrous form. PPI use can worsen iron-deficiency anemia, especially in people with marginal iron status.
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.