NSAIDs may reduce magnesium levels
Non-steroidal anti-inflammatory drugs (ibuprofen, naproxen) can increase renal magnesium excretion and reduce intestinal absorption with long-term use.
Consider magnesium supplementation if using NSAIDs regularly.
Take magnesium separately from NSAIDs
NSAIDs may reduce magnesium levels. Consider magnesium supplementation if using NSAIDs regularly.
Take magnesium separately from NSAIDs
This interaction is rated “Caution” by Formulate. Non-steroidal anti-inflammatory drugs (ibuprofen, naproxen) can increase renal magnesium excretion and reduce intestinal absorption with long-term use.
Studies from our registry that mention magnesium or nsaids. Each links to the primary source and the other Formulate pages citing it.
Mentions magnesium · 2018
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia
Pouteau et al. · PLOS ONE
Mg+B6 combination outperformed Mg alone for stress score reduction in adults with low baseline magnesium.
Mentions magnesium · 2018
The role of magnesium in neurological disorders
Kirkland AE, Sarlo GL, Holton KF · Nutrients
Reviews mechanisms and clinical evidence for magnesium's role in migraine prophylaxis, stress, anxiety, and depression — with strongest RCT support for migraine prevention at 400–600mg/day.
Mentions magnesium · 2016
Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized double-blind placebo-controlled trials
Zhang X, Li Y, Del Gobbo LC, et al. · Hypertension
Meta-analysis of 34 trials (n=2,028) found magnesium supplementation at a median dose of 368mg/day for 3 months significantly reduced systolic BP by 2.00 mmHg and diastolic BP by 1.78 mmHg.
Mentions magnesium · 2016
Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults
Liu et al. · Journal of Alzheimer's Disease
Magnesium L-threonate (Magtein) improved cognitive ability in older adults with cognitive concerns over 12 weeks.
Mentions nsaids · 2014
Efficacy and safety of curcumin for osteoarthritis of the knee: 4-week study compared to ibuprofen
Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. · Clinical Interventions in Aging
4-week non-inferiority RCT (n=367) found C. longa extract 1500mg/day produced similar pain and function improvements to ibuprofen 1200mg/day, with fewer GI adverse events.
Mentions magnesium · 2012
The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial
Abbasi B, Kimiagar M, Sadeghniiat K, et al. · Journal of Research in Medical Sciences
8-week RCT in elderly with insomnia: 500mg/day magnesium significantly improved subjective insomnia score, sleep efficiency, sleep onset latency, and serum melatonin concentration.
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Muscle cramps, twitching eyelids, and poor sleep may signal low magnesium. Learn all 8 signs, why standard blood tests miss it, and how to fix it.
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Discover who actually needs electrolyte supplements, the real science on sodium, and a DIY fix for keto flu symptoms — for about 15 cents a day.
Other interactions to know
PPIs can cause hypomagnesemia
High calcium can impair magnesium absorption
Magnesium may enhance BP lowering effect
PPIs impair magnesium absorption
Magnesium may reduce thyroid med absorption
Magnesium needed for vitamin D activation
Complementary sleep support
Both support sleep through different mechanisms
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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