High-dose magnesium may slightly reduce zinc absorption
Very high magnesium doses (>142mg) may modestly reduce zinc absorption. Normal supplemental doses are fine together.
Generally fine to take together at normal doses.
Can take together; separate only if taking very high doses
High-dose magnesium may slightly reduce zinc absorption. Generally fine to take together at normal doses.
Can take together; separate only if taking very high doses
This interaction is rated “Info” by Formulate. Very high magnesium doses (>142mg) may modestly reduce zinc absorption. Normal supplemental doses are fine together.
Studies from our registry that mention magnesium or zinc. Each links to the primary source and the other Formulate pages citing it.
Mentions magnesium · 2018
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia
Pouteau et al. · PLOS ONE
Mg+B6 combination outperformed Mg alone for stress score reduction in adults with low baseline magnesium.
Mentions magnesium · 2018
The role of magnesium in neurological disorders
Kirkland AE, Sarlo GL, Holton KF · Nutrients
Reviews mechanisms and clinical evidence for magnesium's role in migraine prophylaxis, stress, anxiety, and depression — with strongest RCT support for migraine prevention at 400–600mg/day.
Mentions zinc · 2017
Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage
Hemilä H · JRSM Open
Meta-analysis of 7 RCTs (n=575) found zinc lozenges (≥75mg/day elemental zinc) shortened cold duration by ~33%, with no significant difference between acetate and gluconate forms.
Mentions magnesium · 2016
Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized double-blind placebo-controlled trials
Zhang X, Li Y, Del Gobbo LC, et al. · Hypertension
Meta-analysis of 34 trials (n=2,028) found magnesium supplementation at a median dose of 368mg/day for 3 months significantly reduced systolic BP by 2.00 mmHg and diastolic BP by 1.78 mmHg.
Mentions magnesium · 2016
Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults
Liu et al. · Journal of Alzheimer's Disease
Magnesium L-threonate (Magtein) improved cognitive ability in older adults with cognitive concerns over 12 weeks.
Mentions zinc · 2013
Oral zinc for the common cold (Cochrane Review)
Singh M, Das RR · Cochrane Database of Systematic Reviews
Cochrane review of 18 RCTs found zinc reduced common cold duration and severity in healthy adults when taken within 24 hours of symptom onset, though adverse effects (taste disturbance, nausea) were common.
Guide
Magnesium Glycinate vs Citrate vs Oxide: Which Form Actually Absorbs?
Glycinate (80% absorbed) vs citrate (50%) vs oxide (4%) — with elemental-dose math, side effects, and picks for sleep, constipation, and cognition.
Roundup
Best Magnesium Supplements 2026, Ranked by Clinical Evidence
Learn which magnesium form actually matches your goal. We scored glycinate, threonate, and citrate on absorption, dose accuracy, and third-party testing.
Guide
8 Signs of Magnesium Deficiency – 2026 Guide
Muscle cramps, twitching eyelids, and poor sleep may signal low magnesium. Learn all 8 signs, why standard blood tests miss it, and how to fix it.
Guide
Zinc Supplement Guide 2026: Evidence-Based & Ranked
Learn which zinc forms actually shorten colds, how dosing affects testosterone and copper balance, and who faces the highest deficiency risk.
Other interactions to know
Zinc depletes copper over time
PPIs can cause hypomagnesemia
Zinc and iron compete for absorption
High calcium can impair magnesium absorption
Calcium may reduce zinc absorption
Magnesium may enhance BP lowering effect
PPIs impair magnesium absorption
NSAIDs may reduce magnesium levels
Check your full stack in the free interaction checker.
The free checker lets you add any combination of supplements and medications at once. The free web app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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