Vitamin E protects omega-3 fats from oxidation
Omega-3 fatty acids are highly prone to peroxidation both on the shelf and in the body. Most quality fish oil products already include mixed tocopherols as an antioxidant for this reason.
Choose a fish oil that lists mixed tocopherols on the label. No need to separately megadose vitamin E.
Can take together
Vitamin E protects omega-3 fats from oxidation. Choose a fish oil that lists mixed tocopherols on the label. No need to separately megadose vitamin E.
Can take together
This interaction is rated “Synergy” by Formulate. Omega-3 fatty acids are highly prone to peroxidation both on the shelf and in the body. Most quality fish oil products already include mixed tocopherols as an antioxidant for this reason.
Studies from our registry that mention omega-3 or vitamin e. Each links to the primary source and the other Formulate pages citing it.
Mentions omega-3 · 2020
Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events (STRENGTH)
Nicholls et al. · JAMA
STRENGTH trial (n=13,078). High-dose EPA/DHA did not reduce cardiovascular events — contradicts REDUCE-IT finding.
Mentions omega-3 · 2019
Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association
Skulas-Ray et al. · Circulation
AHA science advisory on triglyceride-lowering effects of 2–4g/day EPA+DHA — typically a 20–30% reduction.
Mentions omega-3 · 2019
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT)
Bhatt DL, Steg PG, Miller M, et al. · New England Journal of Medicine
Double-blind RCT (n=8,179) found high-dose EPA (4g/day) reduced ischemic events by 25% vs placebo in patients with elevated triglycerides on statins — the most convincing cardiovascular benefit data for omega-3s.
Mentions omega-3 · 2019
Efficacy of omega-3 PUFAs in depression: a meta-analysis
Liao et al. · Translational Psychiatry
EPA-dominant formulas (≥60% EPA) were significantly more effective for depression than DHA-dominant ones.
Mentions omega-3 · 2018
Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving 77,917 individuals
Aung et al. · JAMA Cardiology
Large meta-analysis examining cardiovascular outcomes of omega-3 supplementation across 77,917 participants.
Mentions omega-3 · 2015
Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA
Albert et al. · Scientific Reports
Significant percentage of commercially available fish oil exceeded recommended oxidation limits (TOTOX values).
Other interactions to know
Fish oil may increase bleeding risk with warfarin
High-dose vitamin E increases warfarin bleeding risk
High-dose vitamin E may interfere with vitamin K
Fish oil adds to aspirin's antiplatelet effect
Vitamin E enhances aspirin's antiplatelet effect
Fat improves curcumin absorption
Fat improves vitamin D absorption
Check your full stack in the free interaction checker.
The free checker lets you add any combination of supplements and medications at once. The free web app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
Last medically reviewed: