Fish oil adds to aspirin's antiplatelet effect
Both reduce platelet aggregation. Fish oil's effect on bleeding is additive with aspirin. Generally safe in cardiac patients under medical supervision, but increases minor bleeding.
Combination often prescribed for heart health but monitor for excessive bruising.
Watch for nosebleeds, easy bruising, prolonged cuts
Fish oil adds to aspirin's antiplatelet effect. Combination often prescribed for heart health but monitor for excessive bruising.
Watch for nosebleeds, easy bruising, prolonged cuts
This interaction is rated “Caution” by Formulate. Both reduce platelet aggregation. Fish oil's effect on bleeding is additive with aspirin. Generally safe in cardiac patients under medical supervision, but increases minor bleeding.
Studies from our registry that mention aspirin or omega-3. Each links to the primary source and the other Formulate pages citing it.
Mentions aspirin · 2025
Impact of Ginkgo biloba drug interactions on bleeding risk and coagulation profiles
Primary literature · Observational study
Ginkgo + aspirin: bleeding risk OR 1.12 (95% CI 1.07-1.18, p<0.001); abnormal coagulation OR 1.48 (95% CI 1.32-1.66, p<0.001). Ginkgo + clopidogrel: bleeding risk OR 1.10 (95% CI 1.05-1.15, p<0.001); abnormal coagulation OR 1.58 (95% CI 1.40-1.77, p<0.001). Ginkgo + warfarin: NO statistically significant correlation with bleeding or coagulation.
Mentions omega-3 · 2020
Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events (STRENGTH)
Nicholls et al. · JAMA
STRENGTH trial (n=13,078). High-dose EPA/DHA did not reduce cardiovascular events — contradicts REDUCE-IT finding.
Mentions omega-3 · 2019
Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association
Skulas-Ray et al. · Circulation
AHA science advisory on triglyceride-lowering effects of 2–4g/day EPA+DHA — typically a 20–30% reduction.
Mentions omega-3 · 2019
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT)
Bhatt DL, Steg PG, Miller M, et al. · New England Journal of Medicine
Double-blind RCT (n=8,179) found high-dose EPA (4g/day) reduced ischemic events by 25% vs placebo in patients with elevated triglycerides on statins — the most convincing cardiovascular benefit data for omega-3s.
Mentions omega-3 · 2019
Efficacy of omega-3 PUFAs in depression: a meta-analysis
Liao et al. · Translational Psychiatry
EPA-dominant formulas (≥60% EPA) were significantly more effective for depression than DHA-dominant ones.
Mentions omega-3 · 2018
Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving 77,917 individuals
Aung et al. · JAMA Cardiology
Large meta-analysis examining cardiovascular outcomes of omega-3 supplementation across 77,917 participants.
Other interactions to know
Ginkgo + Aspirin: High bleeding risk
Fish oil may increase bleeding risk with warfarin
Vitamin E enhances aspirin's antiplatelet effect
Fat improves curcumin absorption
Fat improves vitamin D absorption
Vitamin E protects omega-3 fats from oxidation
Check your full stack in the free interaction checker.
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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