Vitamin E enhances aspirin's antiplatelet effect
High-dose vitamin E (>400 IU) adds to aspirin's bleeding risk through inhibition of vitamin K-dependent clotting. Combination increases GI bleeding risk.
Use lower vitamin E doses if on daily aspirin. Inform doctor.
Monitor for GI discomfort, dark stools
Vitamin E enhances aspirin's antiplatelet effect. Use lower vitamin E doses if on daily aspirin. Inform doctor.
Monitor for GI discomfort, dark stools
This interaction is rated “Caution” by Formulate. High-dose vitamin E (>400 IU) adds to aspirin's bleeding risk through inhibition of vitamin K-dependent clotting. Combination increases GI bleeding risk.
Studies from our registry that mention aspirin or vitamin e. Each links to the primary source and the other Formulate pages citing it.
Mentions aspirin · 2025
Impact of Ginkgo biloba drug interactions on bleeding risk and coagulation profiles
Primary literature · Observational study
Ginkgo + aspirin: bleeding risk OR 1.12 (95% CI 1.07-1.18, p<0.001); abnormal coagulation OR 1.48 (95% CI 1.32-1.66, p<0.001). Ginkgo + clopidogrel: bleeding risk OR 1.10 (95% CI 1.05-1.15, p<0.001); abnormal coagulation OR 1.58 (95% CI 1.40-1.77, p<0.001). Ginkgo + warfarin: NO statistically significant correlation with bleeding or coagulation.
Mentions vitamin e · 2012
Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease
Loguercio C, Andreone P, Brisc C, et al. · Free Radical Biology and Medicine
12-month RCT (n=138) in NAFLD found a silybin-phosphatidylcholine-vitamin E complex reduced insulin resistance and liver enzymes vs placebo, supporting phytosome forms of silymarin for NAFLD.
Mentions vitamin e · 2009
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Lippman SM, Klein EA, Goodman PJ, et al. · JAMA
Large primary-prevention RCT (n=35,533) found selenium 200µg/day did not prevent prostate cancer — and later follow-up raised concerns about increased type 2 diabetes risk at supplemental doses in selenium-replete populations.
Mentions aspirin · 2008
Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence?
Bone · Mol Nutr Food Res
Reviews multiple controlled studies showing ginkgo does NOT significantly impact hemostasis or aspirin/warfarin safety. Notes EGb 761 (standardized extract) is not generally implicated in case reports. Quality of published case reports is low. Mechanism (ginkgolide B as PAF antagonist) is real but clinically modest.
Mentions aspirin · 2007
Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease
Gardner et al. · Blood Coagul Fibrinolysis
EGb 761 300 mg/day + aspirin 325 mg/day vs placebo + aspirin: no clinically or statistically significant differences on any platelet aggregation or PFA-100 endpoint. No adverse bleeding events.
Other interactions to know
Ginkgo + Aspirin: High bleeding risk
High-dose vitamin E increases warfarin bleeding risk
High-dose vitamin E may interfere with vitamin K
Fish oil adds to aspirin's antiplatelet effect
Vitamin E protects omega-3 fats from oxidation
Check your full stack in the free interaction checker.
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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