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aspirin and vitamin e

Vitamin E enhances aspirin's antiplatelet effect

What's happening

High-dose vitamin E (>400 IU) adds to aspirin's bleeding risk through inhibition of vitamin K-dependent clotting. Combination increases GI bleeding risk.

Recommendation

Use lower vitamin E doses if on daily aspirin. Inform doctor.

Timing

Monitor for GI discomfort, dark stools

Sources

  • — American Journal of Clinical Nutrition
  • — PMID: 11747323

Frequently Asked Questions

Can I take aspirin and vitamin e together?

Vitamin E enhances aspirin's antiplatelet effect. Use lower vitamin E doses if on daily aspirin. Inform doctor.

How should I time aspirin and vitamin e?

Monitor for GI discomfort, dark stools

Is this interaction dangerous?

This interaction is rated “Caution” by Formulate. High-dose vitamin E (>400 IU) adds to aspirin's bleeding risk through inhibition of vitamin K-dependent clotting. Combination increases GI bleeding risk.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.