Skip to main content

vitamin e and warfarin

High-dose vitamin E increases warfarin bleeding risk

What's happening

Vitamin E (>400 IU/day) inhibits vitamin K-dependent clotting and enhances warfarin's effect. Can increase INR and bleeding risk. Mixed tocopherols may have stronger effect than alpha alone.

Recommendation

Avoid high-dose vitamin E on warfarin. If needed, use under 200 IU/day with monitoring.

Timing

Monitor INR closely if combining

Sources

  • — Annals of Internal Medicine
  • — PMID: 14757613

Frequently Asked Questions

Can I take vitamin e and warfarin together?

High-dose vitamin E increases warfarin bleeding risk. Avoid high-dose vitamin E on warfarin. If needed, use under 200 IU/day with monitoring.

How should I time vitamin e and warfarin?

Monitor INR closely if combining

Is this interaction dangerous?

This interaction is rated “Warning” by Formulate. Vitamin E (>400 IU/day) inhibits vitamin K-dependent clotting and enhances warfarin's effect. Can increase INR and bleeding risk. Mixed tocopherols may have stronger effect than alpha alone.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

Open the checkerGet the desktop app

Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.