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dong quai and warfarin

Dong quai significantly increases warfarin effect

What's happening

Dong quai contains coumarins that have direct anticoagulant activity. Combined with warfarin, INR can increase dramatically (case reports of INR >10). Very dangerous interaction.

Recommendation

Absolutely avoid dong quai while on warfarin.

Timing

Do not combine

Sources

  • — Annals of Pharmacotherapy
  • — PMID: 10028195

Frequently Asked Questions

Can I take dong quai and warfarin together?

Dong quai significantly increases warfarin effect. Absolutely avoid dong quai while on warfarin.

How should I time dong quai and warfarin?

Do not combine

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. Dong quai contains coumarins that have direct anticoagulant activity. Combined with warfarin, INR can increase dramatically (case reports of INR >10). Very dangerous interaction.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.