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dan shen and warfarin

Salvia miltiorrhiza potentiates warfarin

What's happening

Dan Shen (Salvia miltiorrhiza) inhibits CYP450 enzymes that metabolize warfarin and has intrinsic anticoagulant properties. Can dramatically increase INR and bleeding.

Recommendation

Do not combine with warfarin. Common in Traditional Chinese Medicine formulas.

Timing

Avoid combination

Sources

  • — Journal of Clinical Pharmacology
  • — PMID: 16505357

Frequently Asked Questions

Can I take dan shen and warfarin together?

Salvia miltiorrhiza potentiates warfarin. Do not combine with warfarin. Common in Traditional Chinese Medicine formulas.

How should I time dan shen and warfarin?

Avoid combination

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. Dan Shen (Salvia miltiorrhiza) inhibits CYP450 enzymes that metabolize warfarin and has intrinsic anticoagulant properties. Can dramatically increase INR and bleeding.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.