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Mineral

Zinc Gluconate

Also known as: zinc gluconate salt, gluconic acid zinc salt

A
Evidence

Zinc gluconate is an organic salt form of zinc commonly used in supplements for immune support and general nutritional repletion. As a mineral cofactor essential for immune function, wound healing, and protein synthesis, zinc gluconate delivers bioavailable zinc with generally good tolerability.

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Daily target & upper limit

11 mg / day · UL 40 mg

Zinc Gluconate has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

Zinc Gluconate dosage reference →

Primary uses

  • Immune system support
  • Wound healing and tissue repair
  • Nutritional deficiency correction
  • Antioxidant enzyme production

How it works

  • Cofactor for 300+ metalloenzymes including superoxide dismutase and RNA polymerase
  • Essential for T-cell development and immune response
  • Required for collagen synthesis and epithelial integrity

Dosage

Typical range
8-25 mg elemental zinc daily
Timing
Can be taken anytime; with or without food
With food
Food may slightly reduce absorption but also reduces GI upset; consider individual tolerance
Duration
Safe for long-term use at recommended doses; RDI is 8-11 mg daily for adults
Special populations
Pregnant/lactating women: 11-13 mg daily; older adults should not exceed 40 mg daily to avoid copper antagonism

Forms

  • powder· 70/100
  • capsule· 70/100
  • tablet· 70/100

Safety

Common side effects

  • Nausea (especially on empty stomach)
  • Metallic taste
  • Mild GI upset
  • Headache (rare)

Contraindications

  • Do not exceed 40 mg/day long-term (risk of copper deficiency and neurological effects)
  • Use caution in patients with copper deficiency
  • Avoid within 2 hours of certain medications (quinolones, tetracyclines)

Known interactions

Evidence notes

Zinc is an essential mineral with extensive RCT evidence for immune function, wound healing, and deficiency correction. Gluconate is a well-characterized, bioavailable form with established safety profile.

Grade A: Multiple well-designed human trials support the main claims.

Cited research for Zinc Gluconate

Clinical studies referenced across Formulate guides that mention zinc gluconate. Each links to the full study page with PubMed source + the guides that cite it.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.