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st johns wort and ssri

Risk of serotonin syndrome

What's happening

St. John's Wort increases serotonin levels. Combined with SSRIs, this can cause dangerous serotonin syndrome.

Recommendation

Do NOT combine with antidepressants without medical supervision.

Timing

Do not combine

Sources

  • — FDA
  • — BMJ

Frequently Asked Questions

Can I take st johns wort and ssri together?

Risk of serotonin syndrome. Do NOT combine with antidepressants without medical supervision.

How should I time st johns wort and ssri?

Do not combine

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. St. John's Wort increases serotonin levels. Combined with SSRIs, this can cause dangerous serotonin syndrome.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.