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cyclosporine and st johns wort

St. John's Wort can cause organ rejection

What's happening

St. John's Wort strongly induces CYP3A4 and P-glycoprotein, dramatically reducing cyclosporine blood levels (up to 50% reduction). Has caused documented cases of acute heart transplant rejection. Life-threatening interaction.

Recommendation

ABSOLUTELY AVOID St. John's Wort if on cyclosporine or any immunosuppressant.

Timing

Do not take at any time while on immunosuppressants

Sources

  • — Lancet
  • — PMID: 10696252
  • — Transplantation

Frequently Asked Questions

Can I take cyclosporine and st johns wort together?

St. John's Wort can cause organ rejection. ABSOLUTELY AVOID St. John's Wort if on cyclosporine or any immunosuppressant.

How should I time cyclosporine and st johns wort?

Do not take at any time while on immunosuppressants

Is this interaction dangerous?

This interaction is rated “Danger” by Formulate. St. John's Wort strongly induces CYP3A4 and P-glycoprotein, dramatically reducing cyclosporine blood levels (up to 50% reduction). Has caused documented cases of acute heart transplant rejection. Life-threatening interaction.

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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.