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Mineral

Magnesium L-Threonate

B
Evidence

Patented form (Magtein) designed to cross blood-brain barrier. Specifically for cognitive enhancement and brain magnesium.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

420 mg / day · UL 350 mg

Magnesium L-Threonate has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

  • Cognitive function
  • Memory support
  • Brain magnesium
  • Neuroprotection

How it works

  • Threonate enables BBB crossing
  • Increases brain Mg levels
  • Enhances synaptic plasticity

Dosage

Typical range
1000-2000 mg threonate (144-288 mg elemental)
Timing
Divided, some at bedtime
With food
Optional
Duration
Benefits take 4-6 weeks
Special populations
Cognitive concerns

Forms

  • Capsule

Safety

Common side effects

  • Headache initially
  • Drowsiness

Contraindications

  • Severe kidney disease

Known interactions

Evidence notes

Unique brain penetration

Grade B: Some human trials support key claims; further confirmation needed.

Cited research for Magnesium L-Threonate

Clinical studies referenced across Formulate guides that mention magnesium l-threonate. Each links to the full study page with PubMed source + the guides that cite it.

Magnesium L-Threonate compared head-to-head

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.