Mineral

Chromium (as Chromium Nicotinate Glycinate Chelate)

Also known as: Chromium Polynicotinate, Chelated Chromium, GTF Chromium, Cr

Evidence

Chromium is a trace mineral that enhances insulin signaling and glucose metabolism by potentiating insulin receptor activity. The nicotinate glycinate chelate form combines chromium with niacin and glycine for improved stability and absorption.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

35 mcg / day

Chromium (as Chromium Nicotinate Glycinate Chelate) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

Blood sugar regulation
Insulin sensitivity support
Glucose metabolism
Carbohydrate metabolism

How it works

Potentiates insulin signaling pathways
Enhances insulin receptor tyrosine kinase activity
Activates glucose transporter GLUT4

Dosage

Typical range: 200-400 mcg daily
Timing: With meals
With food: Recommended; enhances insulin response context
Duration: Safe for long-term use at these doses
Special populations: Diabetes: consult healthcare provider; may require medication adjustment. Renal disease: use with caution.

Forms

Nicotinate Glycinate Chelate· 70/100

Safety

Common side effects

Minimal at typical doses
Headache (rare)
Sleep disturbances (high doses)

Contraindications

Concurrent chromium supplementation from multiple sources

Products containing Chromium (as Chromium Nicotinate Glycinate Chelate)

Top-scoring supplements in our catalog that list Chromium (as Chromium Nicotinate Glycinate Chelate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Basic Nutrients 2/Day

Thorne

Basic Prenatal

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Evidence notes

Good evidence for chromium supporting glucose control in insulin resistance and diabetes. Nicotinate glycinate chelate form has reasonable bioavailability data, though direct comparative evidence vs. other forms is limited.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.