Immune

Yeast Extract (Saccharomyces cerevisiae) Cell Wall with Beta-Glucan

Also known as: Baker's yeast extract, S. cerevisiae cell wall, Yeast beta-glucan, Functional yeast extract

Evidence

Yeast extract cell wall is a source of beta-glucans, polysaccharides that have demonstrated immune-modulating properties in research. The standardized 50% beta-glucan content provides a consistent dose of compounds studied for supporting immune function and inflammatory response.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Immune system support
Inflammatory response modulation
Gut health promotion

How it works

Beta-glucan binding to pattern recognition receptors (Dectin-1) on immune cells
Activation of macrophages and neutrophils
Modulation of inflammatory mediators
Support of barrier function in gastrointestinal tract

Dosage

Typical range: 500-2000 mg daily (typically providing 250-1000 mg beta-glucan)
Timing: Can be taken with or between meals
With food: No requirement; food may enhance absorption of some polysaccharides
Duration: Typically used on an ongoing basis; benefits may take 2-4 weeks to manifest
Special populations: Generally recognized as safe; may be limited in individuals with yeast sensitivities or active yeast infections, though cell wall extracts are generally well-tolerated

Forms

Powder· 70/100
Capsule· 70/100
Tablet· 70/100

Safety

Common side effects

Mild gastrointestinal discomfort in sensitive individuals
Rare allergic reactions in yeast-sensitive persons

Contraindications

Active Candida infection (use with caution)
Severe yeast allergy
Immunocompromised individuals should consult healthcare provider before use

Evidence notes

Beta-glucans from yeast have moderate-to-good clinical evidence for immune support, particularly for upper respiratory infection reduction and immune marker modulation. However, evidence is less robust than for other well-established immune ingredients. Standardization to 50% beta-glucan provides stronger evidence basis than non-standardized yeast extract.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.