Immune
Shiitake Mushroom
Also known as: Lentinula edodes, Lentinus edodes, Shiitake, Shiitake Mushroom Extract (Lentinula edodes)
Shiitake mushroom extract is a fungal ingredient containing bioactive compounds including polysaccharides (beta-glucans) and lentinan, traditionally used to support immune function. Limited clinical evidence supports immune-modulating properties, primarily from observational and preliminary studies.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Immune support
- Cardiovascular health
- Antioxidant
- General wellness
- Immune system support
- Antioxidant support
How it works
- Beta-glucans activate immune cells
- Lentinan enhances natural killer cells
- Antioxidant compounds
Dosage
- Typical range
- 500-3000 mg daily
- Timing
- With meals
- With food
- Yes, improves tolerance
- Duration
- Safe for long-term use
- Special populations
- Immune support seekers
Forms
- Beta-glucan standardized· 100/100
- Hot water extract· 90/100
- Fruiting body· 90/100
- Powder· 80/100
- Powder extract· 70/100
- Capsule· 70/100
- Whole fruiting body powder· 70/100
Safety
Common side effects
- Rare GI upset
- Skin sensitivity in some
Contraindications
- Mushroom allergy
Products containing Shiitake Mushroom
Top-scoring supplements in our catalog that list Shiitake Mushroom on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Good evidence for immune modulation and beta-glucan benefits
Grade B: Some human trials support key claims; further confirmation needed.
Related in Immune
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.