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Immune

EpiCor® (Saccharomyces cerevisiae Fermentate)

Also known as: Saccharomyces cerevisiae fermentate, S. cerevisiae fermentate, EpiCor, baker's yeast fermentate

C
Evidence

EpiCor is a fermented baker's yeast (Saccharomyces cerevisiae) whole-cell extract studied primarily for immune support and antioxidant effects. Clinical evidence is moderate and primarily limited to specific proprietary formulations, with benefits most established for respiratory health and innate immune markers.

Primary uses

  • Immune system support
  • Respiratory health
  • Antioxidant activity
  • Immune response enhancement

How it works

  • Modulation of innate immunity via pattern recognition receptors
  • Beta-glucan and polysaccharide immune signaling
  • Antioxidant activity from phenolic compounds and metabolites
  • Potential enhancement of natural killer cell and neutrophil function

Dosage

Typical range
500 mg daily
Timing
Can be taken with or without meals; consistent daily timing recommended
With food
Not required; may be taken with or without food
Duration
Studies typically use 8-12 weeks; longer-term safety data limited
Special populations
Generally recognized as safe; limited data in pregnancy, nursing, or immunocompromised individuals

Forms

  • Capsule· 70/100
  • Powder· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Rare: mild gastrointestinal symptoms
  • Rare: allergic reactions in yeast-sensitive individuals

Contraindications

  • Confirmed Saccharomyces cerevisiae allergy or intolerance
  • Severe immunocompromise (theoretical caution with immune-stimulating compounds)
  • Caution with candida or active yeast infections (consult healthcare provider)

Evidence notes

Moderate preliminary evidence from several RCTs showing benefits for respiratory symptoms and immune markers; however, studies are mostly industry-sponsored, limited in scope, and use the proprietary EpiCor formulation specifically, limiting generalizability to other S. cerevisiae fermentates. Evidence grade does not reach B due to small sample sizes and narrow clinical endpoints.

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.