Immune
Beta Glucan 1,3/1,6 (from Saccharomyces cerevisiae)
Also known as: Baker's yeast beta-glucan, Yeast beta-glucan, β-glucan 1,3/1,6, Saccharomyces cerevisiae beta-glucan
Beta-glucan 1,3/1,6 from baker's yeast is a soluble polysaccharide that may support immune function by enhancing natural killer cell activity and promoting a healthy inflammatory response. Moderate clinical evidence supports its use for general immune support, particularly during periods of stress or seasonal challenges.
Primary uses
- Immune system support
- Natural killer cell activation
- Inflammatory response modulation
- General wellness
How it works
- Binds to pattern recognition receptors (Dectin-1) on innate immune cells
- Stimulates macrophage and natural killer cell activity
- Enhances complement pathway activation
- Modulates cytokine production
Dosage
- Typical range
- 250-500 mg daily
- Timing
- With meals or as directed on label
- With food
- May enhance absorption; typically taken with food
- Duration
- Consistent daily use for 4+ weeks may be needed for optimal immune support effects
- Special populations
- Generally recognized as safe for most adults; limited data in pregnancy/lactation
Forms
- Capsules· 70/100
- Tablets· 70/100
- Powder· 70/100
Safety
Common side effects
- Rare mild gastrointestinal effects (nausea, digestive changes)
- Mild headache in isolated cases
Contraindications
- Severe immunocompromised states (immunosuppressive therapy) — may cause excessive immune activation; consult healthcare provider
- Known baker's yeast allergy or sensitivity
Evidence notes
Multiple RCTs demonstrate immune-supportive effects, particularly for NK cell activity and respiratory health in stressed populations. However, variation in extraction methods and dosing protocols limits generalizability; most robust data exists for specific yeast beta-glucan preparations.
Grade B: Some human trials support key claims; further confirmation needed.
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