Heart Health
Nattokinase
Also known as: Natto enzyme, NK
Enzyme from natto with fibrinolytic activity. May support healthy circulation and blood viscosity.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Circulation
- Blood viscosity
- Clot prevention
- Blood pressure
How it works
- Fibrinolytic activity
- May reduce blood viscosity
- Blood pressure support
Dosage
- Typical range
- 2000-4000 FU daily
- Timing
- Any time, often morning
- With food
- Optional
- Duration
- Ongoing for circulation
- Special populations
- Circulation support, travel, sitting jobs
Forms
- Capsules
Safety
Common side effects
- Rare
Contraindications
- Bleeding disorders
- Before surgery
- Taking blood thinners
Known interactions
Evidence notes
Fibrinolytic enzyme
Grade B: Some human trials support key claims; further confirmation needed.
Related in Heart Health
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.