Nattokinase has potent blood-thinning properties
Nattokinase is a fibrinolytic enzyme that directly breaks down fibrin and inhibits platelet aggregation. Combined with any anticoagulant (warfarin, aspirin, DOACs), dramatically increases bleeding risk.
Do NOT take nattokinase with any blood thinner. Consult doctor before use.
Avoid combination entirely; stop 2 weeks before surgery
Nattokinase has potent blood-thinning properties. Do NOT take nattokinase with any blood thinner. Consult doctor before use.
Avoid combination entirely; stop 2 weeks before surgery
This interaction is rated “Danger” by Formulate. Nattokinase is a fibrinolytic enzyme that directly breaks down fibrin and inhibits platelet aggregation. Combined with any anticoagulant (warfarin, aspirin, DOACs), dramatically increases bleeding risk.
Studies from our registry that mention blood thinners or nattokinase. Each links to the primary source and the other Formulate pages citing it.
Other interactions to know
Ginkgo may modestly increase bleeding risk with warfarin, aspirin, or clopidogrel. Evidence is mixed but precaution is warranted.
Melatonin may affect blood clotting
Check your full stack in the free interaction checker.
The free checker lets you add any combination of supplements and medications at once. The free web app goes further — every stack change surfaces interaction alerts automatically.
Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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