Antioxidant

Naringenin

Also known as: Grapefruit flavonoid

Evidence

Grapefruit flavonoid with metabolic and liver-protective properties. Supports lipid metabolism and insulin sensitivity.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Metabolic support
Liver protection
Lipid metabolism
Insulin sensitivity

How it works

Activates AMPK
Supports lipid metabolism
Hepatoprotective
Improves insulin sensitivity

Dosage

Typical range: 100-500mg daily
Timing: With meals
With food: Yes
Duration: Long-term appears safe
Special populations: Metabolic support, liver health

Forms

Capsule

Safety

Common side effects

Well tolerated

Contraindications

Many medications (CYP3A4 substrates)

Evidence notes

Promising metabolic research, grapefruit drug interactions apply

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.