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Antioxidant

Sophorа Japonica Extract (Bud) – Quercetin 95% Anhydrous

Also known as: Japanese Pagoda Tree Extract, Anhydrous Quercetin, Quercetin Anhydrous, Sophora japonica bud extract

B
Evidence

Quercetin is a widely-studied polyphenolic flavonoid found in plants like Sophora japonica; it functions primarily as an antioxidant and has preliminary evidence for anti-inflammatory and cardiovascular support effects.

Primary uses

  • Antioxidant support
  • Anti-inflammatory effects
  • Cardiovascular health
  • Allergy/histamine response modulation
  • General wellness

How it works

  • Potent free radical scavenging via polyphenolic structure
  • Mast cell stabilization and histamine modulation
  • NF-κB pathway inhibition and pro-inflammatory cytokine reduction
  • Endothelial function improvement

Dosage

Typical range
500–1,200 mg daily in divided doses
Timing
With meals for better absorption and reduced GI irritation
With food
Recommended; food enhances bioavailability, particularly with fat
Duration
Suitable for long-term use; benefits may take 4–8 weeks to manifest
Special populations
Pregnant/nursing women should consult a healthcare provider; may interact with certain medications affecting drug metabolism

Forms

  • Anhydrous powder· 70/100
  • Tablet· 70/100
  • Capsule· 70/100
  • Standardized extract· 70/100

Safety

Common side effects

  • Mild headache (rare)
  • Nausea or GI upset at high doses
  • Tingling in extremities (very rare, high doses)

Contraindications

  • Bleeding disorders or concurrent anticoagulant/antiplatelet therapy (may have mild platelet effects)
  • Pregnancy/nursing (limited safety data)
  • Kidney disease (metabolized hepatically; use with caution at high doses)

Evidence notes

Quercetin has robust in vitro and animal model evidence plus multiple human clinical trials supporting antioxidant, anti-inflammatory, and mild cardiovascular benefits; however, effect sizes in humans are often modest and some trials show mixed results. Grade B reflects good cumulative evidence with some limitations in translation to clinical outcomes.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.