Antioxidant

Sophorа Japonica Extract (Bud) – Quercetin 95% Anhydrous

Also known as: Japanese Pagoda Tree Extract, Anhydrous Quercetin, Quercetin Anhydrous, Sophora japonica bud extract

Evidence

Quercetin is a widely-studied polyphenolic flavonoid found in plants like Sophora japonica; it functions primarily as an antioxidant and has preliminary evidence for anti-inflammatory and cardiovascular support effects.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Antioxidant support
Anti-inflammatory effects
Cardiovascular health
Allergy/histamine response modulation
General wellness

How it works

Potent free radical scavenging via polyphenolic structure
Mast cell stabilization and histamine modulation
NF-κB pathway inhibition and pro-inflammatory cytokine reduction
Endothelial function improvement

Dosage

Typical range: 500–1,200 mg daily in divided doses
Timing: With meals for better absorption and reduced GI irritation
With food: Recommended; food enhances bioavailability, particularly with fat
Duration: Suitable for long-term use; benefits may take 4–8 weeks to manifest
Special populations: Pregnant/nursing women should consult a healthcare provider; may interact with certain medications affecting drug metabolism

Forms

Anhydrous powder· 70/100
Tablet· 70/100
Capsule· 70/100
Standardized extract· 70/100

Safety

Common side effects

Mild headache (rare)
Nausea or GI upset at high doses
Tingling in extremities (very rare, high doses)

Contraindications

Bleeding disorders or concurrent anticoagulant/antiplatelet therapy (may have mild platelet effects)
Pregnancy/nursing (limited safety data)
Kidney disease (metabolized hepatically; use with caution at high doses)

Products containing Sophorа Japonica Extract (Bud) – Quercetin 95% Anhydrous

Top-scoring supplements in our catalog that list Sophorа Japonica Extract (Bud) – Quercetin 95% Anhydrous on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Quercetin has robust in vitro and animal model evidence plus multiple human clinical trials supporting antioxidant, anti-inflammatory, and mild cardiovascular benefits; however, effect sizes in humans are often modest and some trials show mixed results. Grade B reflects good cumulative evidence with some limitations in translation to clinical outcomes.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.