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Antioxidant

Quercetin Dihydrate (from Sophora japonica bud extract)

Also known as: quercetin, quercetin dihydrate, sophora quercetin

B
Evidence

A plant-derived bioflavonoid extracted from Sophora japonica buds with potent antioxidant and anti-inflammatory properties. Quercetin is one of the most abundant flavonoids in plant foods.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Antioxidant support
  • Anti-inflammatory response
  • Seasonal allergy support
  • Immune modulation

How it works

  • Mast cell stabilization
  • Quercetin may reduce histamine release
  • Free radical scavenging
  • NF-κB pathway modulation

Dosage

Typical range
250–1000 mg daily, often split into 2–3 doses
Timing
With meals for improved absorption
With food
With food; bioavailability enhanced by fat or quercetin transporters
Duration
Safe for continuous use; effects may accumulate over weeks
Special populations
Generally safe; those on blood thinners should monitor with healthcare provider

Forms

  • powder· 70/100
  • capsule· 70/100
  • dihydrate· 70/100

Safety

Common side effects

  • Rare; headache or stomach upset at high doses

Contraindications

  • Caution with anticoagulant/antiplatelet medications

Products containing Quercetin Dihydrate (from Sophora japonica bud extract)

Top-scoring supplements in our catalog that list Quercetin Dihydrate (from Sophora japonica bud extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Quercetin Phytosome
92
Thorne
Quercetin Complex
90
Thorne
Advanced Nutrients
88
Thorne
Pre-Workout Elite
88
See all products →

Evidence notes

Good evidence for antioxidant and anti-inflammatory effects; moderate evidence for seasonal allergy support. Bioavailability improved with dihydrate form.

Grade B: Some human trials support key claims; further confirmation needed.

Cited research for Quercetin Dihydrate (from Sophora japonica bud extract)

Clinical studies referenced across Formulate guides that mention quercetin dihydrate (from sophora japonica bud extract). Each links to the full study page with PubMed source + the guides that cite it.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.