Antioxidant
Naringin Extract (Citrus hongheensis)
Also known as: naringin, citrus hongheensis extract, pomelo extract, Chinese grapefruit extract
Naringin is a flavonoid compound found in citrus fruits, particularly Citrus hongheensis, with preliminary evidence for antioxidant and anti-inflammatory properties. Most research is limited to in vitro and animal studies; human clinical evidence remains sparse.
Primary uses
- Antioxidant support
- Anti-inflammatory support
- Cardiovascular health
- Metabolic health
How it works
- Flavonoid antioxidant activity
- Free radical scavenging
- Modulation of inflammatory pathways
- Potential inhibition of cytochrome P450 enzymes
Dosage
- Typical range
- 100-500 mg daily
- Timing
- With meals
- With food
- May be better absorbed with fat-containing meals
- Duration
- Long-term safety data in humans is limited; typical supplementation periods in studies range 4-12 weeks
- Special populations
- Pregnant/nursing women should consult a healthcare provider before use
Forms
- Powder extract· 70/100
Safety
Common side effects
- Generally well-tolerated in studied doses
- Potential gastrointestinal upset in sensitive individuals
Contraindications
- Caution with medications metabolized by CYP3A4 (naringin may inhibit this enzyme)
- Potential interaction with certain statins and immunosuppressants
Evidence notes
Limited human clinical trials; most evidence comes from in vitro and animal studies. Some preliminary data on antioxidant and cardiovascular effects, but insufficient high-quality RCT evidence in humans to establish efficacy.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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