Amino Acid
Glycine (Longevity Dose)
Also known as: Glycine, Aminoacetic acid
Simplest amino acid with emerging longevity benefits at higher doses. Supports glutathione, collagen, sleep, and may mimic methionine restriction.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Glycine (Longevity Dose) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nutricost Glycine Powder | 92 A | $0.17 |
| 2 | Thorne Glycine | 92 A | $0.25 |
| 3 | Pure Encapsulations Glycine | 92 A | $0.58 |
| 4 | Life Extension Glycine | 92 A | $0.13 |
| 5 | NutraBio Glycine Powder | 92 A | $0.13 |
| 6 | Pure Encapsulations NAC + Glycine powder | 88 A | $1.27 |
| 7 | Pure Encapsulations Pure Tranquility Liquid | 87 A | $1.76 |
| 8 | Life Extension Optimized Carnitine | 87 A | $0.78 |
| 9 | Thorne MediClear-SGS™ - Vanilla | 86 A- | $2.10 |
| 10 | Vital Nutrients Glycine Powder | 85 A- | $0.60 |
| 11 | NOW Foods Double Strength 5-HTP | 84 A- | $0.37 |
| 12 | Swanson GABAplex with L-Tyrosine & L-Theanine | 84 A- | $0.28 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Glycine (Longevity Dose) should I take?
The typical range is 3-15g daily for longevity; 3g for sleep. Safe long-term
When should I take Glycine (Longevity Dose)?
Before bed for sleep; divided for longevity. Optional.
Which form of Glycine (Longevity Dose) is best?
Powder — Most economical for high doses. Other forms in the catalog: Capsules.
Is Glycine (Longevity Dose) safe?
Commonly reported: Sweet taste, Soft stools at high doses. Serious warnings: None significant. Safe
Which Glycine (Longevity Dose) supplement scores highest?
Nutricost Glycine Powder, at 92/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Daily target & upper limit
3 g / dayGlycine (Longevity Dose) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Glycine (Longevity Dose) dosage reference →Primary uses
- Longevity
- Sleep
- Glutathione support
- Collagen synthesis
How it works
- Glutathione precursor
- Collagen building block
- May mimic methionine restriction
- Inhibitory neurotransmitter
Dosage
- Typical range
- 3-15g daily for longevity; 3g for sleep
- Timing
- Before bed for sleep; divided for longevity
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Sleep, longevity, glutathione support
Forms
- Powder
- Capsules
Safety
Common side effects
- Sweet taste
- Soft stools at high doses
Contraindications
- None
Products containing Glycine (Longevity Dose)
Top-scoring supplements in our catalog that list Glycine (Longevity Dose) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Traditional uses plus emerging longevity research
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Glycine (Longevity Dose)
Clinical studies referenced across Formulate guides that mention glycine (longevity dose). Each links to the full study page with PubMed source + the guides that cite it.
- Kawai N, Sakai N, Okuro M, et al. (2015)Neuropsychopharmacology
The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus
- Bannai and Kawai (2012)Journal of Pharmacological Sciences
New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep
- Yamadera W, Inagawa K, Chiba S, et al. (2007)Sleep and Biological Rhythms
Glycine ingestion improves subjective sleep quality in human volunteers
Related in Amino Acid
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.