Performance

Betaine (TMG)

Also known as: Trimethylglycine, TMG, Betaine anhydrous

Evidence

Methyl donor supporting strength, power, and body composition. Also important for homocysteine metabolism.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

Find the best Betaine (TMG) supplements — free

See Betaine (TMG) products scored on dose & form, then track your intake in the app.

Open app →

Primary uses

Strength
Power
Body composition
Methylation

How it works

Osmolyte protecting cells
Methyl donor for homocysteine
May increase power output

Dosage

Typical range: 2.5-6 g daily
Timing: Any time or pre-workout
With food: Optional
Duration: Safe long-term
Special populations: Athletes, high homocysteine

Forms

Powder
Capsules

Safety

Common side effects

Fishy body odor at high doses
GI upset

Contraindications

None

Products containing Betaine (TMG)

Top-scoring supplements in our catalog that list Betaine (TMG) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

Methyl-Guard®

Nutricost

Betaine Anhydrous (TMG) Capsules

Evidence notes

Emerging performance benefits

Grade B: Some human trials support key claims; further confirmation needed.

Related in Performance

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Where does Betaine (TMG) fit in your stack?

Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.

Build my stack

2 questions · free · no account needed to start

Also on iPhone — get the free app

📬 Get new guides in your inbox

Evidence-based supplement guides, no spam

We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.