Performance
Betaine (TMG)
Also known as: Trimethylglycine, TMG, Betaine anhydrous
Methyl donor supporting strength, power, and body composition. Also important for homocysteine metabolism.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Betaine (TMG) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Methyl-Guard® | 93 A | $0.93 |
| 2 | Nutricost TMG Capsules | 92 A | $0.10 |
| 3 | Nutricost Betaine Anhydrous (TMG) Capsules | 91 A | $0.18 |
| 4 | Thorne Methyl-Guard Plus | 91 A | $2.07 |
| 5 | Transparent Labs BULK Pre-Workout | 90 A | $1.67 |
| 6 | Nutricost Pre-Workout For Women Powder | 89 A | $0.73 |
| 7 | Nutricost Pre-Workout Complex | 89 A | $0.83 |
| 8 | Nutricost Betaine HCI + Pepsin Capsules | 88 A | $0.08 |
| 9 | Thorne Betaine HCL & Pepsin | 88 A | $0.42 |
| 10 | Thorne SynaQuell +™ | 88 A | $1.47 |
| 11 | Thorne Multi Enzyme | 87 A | $0.56 |
| 12 | Codeage Methylfolate B Complex+ | 87 A | $0.62 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Betaine (TMG) should I take?
The typical range is 2.5-6 g daily. Safe long-term
When should I take Betaine (TMG)?
Any time or pre-workout. Optional.
Which form of Betaine (TMG) is best?
Powder — Often in pre-workouts. Other forms in the catalog: Capsules.
Is Betaine (TMG) safe?
Commonly reported: Fishy body odor at high doses, GI upset. Serious warnings: None. May support liver
Which Betaine (TMG) supplement scores highest?
Thorne Methyl-Guard®, at 93/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Strength
- Power
- Body composition
- Methylation
How it works
- Osmolyte protecting cells
- Methyl donor for homocysteine
- May increase power output
Dosage
- Typical range
- 2.5-6 g daily
- Timing
- Any time or pre-workout
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Athletes, high homocysteine
Forms
- Powder
- Capsules
Safety
Common side effects
- Fishy body odor at high doses
- GI upset
Contraindications
- None
Products containing Betaine (TMG)
Top-scoring supplements in our catalog that list Betaine (TMG) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Emerging performance benefits
Grade B: Some human trials support key claims; further confirmation needed.
Related in Performance
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Betaine (TMG) fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.