Performance
Anhydrous Caffeine
Also known as: caffeine anhydrous, caffeine powder, USP caffeine
Anhydrous caffeine is pure, water-free caffeine that provides rapid mental alertness and physical performance enhancement. It is the most common form of caffeine in dietary supplements due to stability and concentrated potency.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Mental alertness and focus
- Physical performance and endurance
- Fatigue reduction
- Cognitive function enhancement
- Pre-workout supplementation
How it works
- Adenosine receptor antagonism in the CNS
- Increased dopamine and norepinephrine release
- Improved neuromuscular transmission
- Enhanced fat oxidation
Dosage
- Typical range
- 100-400 mg daily, typically 3-6 mg/kg body weight
- Timing
- Morning or early afternoon; peak effects at 30-60 minutes
- With food
- Can be taken with or without food; taking with food may slightly delay absorption
- Duration
- Half-life of 3-5 hours; effects typically last 4-6 hours
- Special populations
- Limit to <400 mg/day; avoid in evening; reduce doses in pregnancy (consult healthcare provider), in sensitive individuals, or with anxiety disorders
Forms
- powder· 70/100
- capsule· 70/100
- tablet· 70/100
Safety
Common side effects
- Jitteriness
- Anxiety
- Sleep disruption
- Increased heart rate
- Tremors
- Headaches with overdose or withdrawal
Contraindications
- Uncontrolled hypertension
- Cardiovascular disease
- Severe anxiety or panic disorders
- Pregnancy (limit to <200 mg/day)
- Lactation (passes into breast milk)
- Insomnia or sleep disorders
Products containing Anhydrous Caffeine
Top-scoring supplements in our catalog that list Anhydrous Caffeine on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Extensive peer-reviewed research confirms efficacy for alertness, focus, and physical performance across hundreds of RCTs. One of the most well-studied dietary supplements.
Grade A: Multiple well-designed human trials support the main claims.
Related in Performance
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.