What the reviews found
Supplements for Skin
4 where systematic reviews concluded a benefit, 1 with mixed findings, 2 where they concluded no effect. Every line quotes the review and links it, so you can read the sentence yourself.
Reviews found a benefit
Systematic reviews concluded these improve an outcome tied to skin, and none concluded no effect.
- Benefitskin ageing (wrinkles, elasticity, moisture)
“Ingestion and/or topical usages of ASX may be effective in reducing skin ageing and have promising cosmetical potential, as it improves moisture content and elasticity and reduces wrinkles.” PMID 34578794 · 2 reviews
- Lactobacillus paracasei1 review citedBenefitatopic dermatitis
“Certain probiotic preparations demonstrate efficacy in reducing the risk of developing atopic dermatitis when administered to pregnant women, infants, or both.” PMID 33811784
- Benefitskin photoaging
“supplementation with tomato and lycopene could reduce skin erythema formation and improve the appearance and pigmentation of the skin, thereby preventing light-induced skin photodamage and skin photoaging.” PMID 36606553
- Benefitscorad score in atopic dermatitis
“A meta-analysis of 20 RCTs assessing probiotics, alone or combined with prebiotics, revealed a significant reduction in SCORAD scores, suggesting a consistent trend in alleviating AD symptoms in children without food allergies.” PMID 38783644
Mixed: a benefit on one measure, no effect on another
- Collagen5 reviews citedBenefitskin hydration
“a grouped analysis of studies showed favorable results of hydrolyzed collagen supplementation compared with placebo in terms of skin hydration, elasticity, and wrinkles” PMID 33742704 · 2 reviews
Benefitskin elasticity“The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, p < 0.00001) and elasticity (test for overall effect: Z = 4.49, p < 0.00001) compared to the placebo group.” PMID 37432180 · 2 reviews
Benefitskin wrinkles“ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging, as it reduces wrinkles and improves skin elasticity and hydration.” PMID 33742704
3 more review findings.
Reviews found no effect
Reviews studied these for an outcome tied to skin and concluded they made no difference.
- Top-scored productNutricost Aloe Vera Capsules2 reviews cited87No effectradiodermatitis
“Aloe vera and emu oil were equivalent or less effective than standard care.” PMID 33063778
No effectradiation-induced skin injury and sunburn protection“Topical application of aloe vera is not an effective prevention for radiation-induced injuries and has no sunburn or suntan protection.” PMID 19218914
- No effectskin wrinkling
“No significant reduction was noted for green tea, Vitaphenol® (a combination of green and white teas, mangosteen and pomegranate extract) or maca root.” PMID 21087067
Not enough to say
Reviews of Hyaluronic Acid, Lutein, Vitamin E could not conclude either way on skin.
How this page is built
Each finding is the conclusion a set of systematic reviews reached on one outcome — whether an ingredient helped, made no difference, or could not be judged — with a sentence quoted from one review, checked to appear in its PubMed abstract. It records the direction, not the size, of an effect. Reviews run in populations such as people with cancer, pregnancy, surgery or children are left out, because applying them to a general reader would mislead. Evidence last refreshed September 2026. Abstracts courtesy of the U.S. National Library of Medicine (PubMed).
Other goals
Educational only. A review finding a benefit on average does not mean a supplement will help you, or that it is safe alongside your medication. If you are treated for skin, talk to your clinician before adding anything.