Longevity
Urolithin A
Also known as: UA, Mitopure
Gut-derived metabolite that activates mitophagy, clearing damaged mitochondria. Most people don't produce it efficiently, making supplementation valuable.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Common questions
How much Urolithin A should I take?
The typical range is 250-1000mg daily. Safe long-term, benefits build over weeks
When should I take Urolithin A?
Morning with food. Yes.
Which form of Urolithin A is best?
Capsule — Standard. Other forms in the catalog: Powder.
Is Urolithin A safe?
Commonly reported: Well tolerated, Mild GI initially. Serious warnings: None significant. Safe
Which Urolithin A supplement scores highest?
Pure Encapsulations Renual, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Mitophagy
- Mitochondrial health
- Muscle function
- Longevity
How it works
- Activates mitophagy (clears damaged mitochondria)
- Improves muscle endurance
- Enhances mitochondrial function
- Anti-aging effects in studies
Dosage
- Typical range
- 250-1000mg daily
- Timing
- Morning with food
- With food
- Yes
- Duration
- Safe long-term, benefits build over weeks
- Special populations
- Age-related muscle decline, mitochondrial support
Forms
- Capsule
- Powder
Safety
Common side effects
- Well tolerated
- Mild GI initially
Contraindications
- None established
Products containing Urolithin A
Top-scoring supplements in our catalog that list Urolithin A on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Strong clinical evidence for mitochondrial and muscle benefits
Grade B: Some human trials support key claims; further confirmation needed.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.