Longevity
PQQ (Pyrroloquinoline Quinone)
Also known as: PQQ, Methoxatin, BioPQQ
Redox cofactor supporting mitochondrial biogenesis and cognitive function. One of few compounds shown to stimulate new mitochondria formation.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every PQQ (Pyrroloquinoline Quinone) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations SR-CoQ10 with PQQ | 91 A | $3.13 |
| 2 | Double Wood PQQ (Pyrroloquinoline quinone) Supplement | 90 A | $0.33 |
| 3 | Life Extension Mitochondrial Energy Optimizer with PQQ | 90 A | $1.63 |
| 4 | Natural Factors PQQ-10 | 90 A | $1.47 |
| 5 | Doctor's Best CoQ10 100 mg, PQQ 20 mg, 60 Veggie Caps | 88 A | $0.58 |
| 6 | Transparent Labs Longevity Healthy Aging Complex | 87 A | $2.67 |
| 7 | Life Extension Super Ubiquinol COQ10 with PQQ | 87 A | $1.13 |
| 8 | Seed PM-02™ Sleep + Restore Supplement | 86 A- | $1.17 |
| 9 | Global Healing CoQ10 & BioPQQ with Shilajit | 84 A- | $1.17 |
| 10 | Pure Encapsulations Ultra B-Complex with PQQ | 81 A- | $1.51 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much PQQ (Pyrroloquinoline Quinone) should I take?
The typical range is 10-20mg daily. Safe long-term
When should I take PQQ (Pyrroloquinoline Quinone)?
Morning. Optional.
Which form of PQQ (Pyrroloquinoline Quinone) is best?
Capsule — Standard. Other forms in the catalog: Lozenge.
Is PQQ (Pyrroloquinoline Quinone) safe?
Commonly reported: Well tolerated, Headache rare, Insomnia if taken late. Serious warnings: None significant. Safe
Which PQQ (Pyrroloquinoline Quinone) supplement scores highest?
Pure Encapsulations SR-CoQ10 with PQQ, at 91/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Mitochondrial biogenesis
- Cognitive support
- Energy
- Neuroprotection
How it works
- Stimulates PGC-1alpha for new mitochondria
- Potent antioxidant (redox cycling)
- Nerve growth factor support
- Protects neurons from oxidative stress
Dosage
- Typical range
- 10-20mg daily
- Timing
- Morning
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Mitochondrial support, cognitive enhancement
Forms
- Capsule
- Lozenge
Safety
Common side effects
- Well tolerated
- Headache rare
- Insomnia if taken late
Contraindications
- None established
Products containing PQQ (Pyrroloquinoline Quinone)
Top-scoring supplements in our catalog that list PQQ (Pyrroloquinoline Quinone) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Unique mitochondrial biogenesis support, growing research
Grade B: Some human trials support key claims; further confirmation needed.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.