Longevity
PQQ (Pyrroloquinoline Quinone)
Also known as: PQQ, Methoxatin, BioPQQ
Redox cofactor supporting mitochondrial biogenesis and cognitive function. One of few compounds shown to stimulate new mitochondria formation.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Mitochondrial biogenesis
- Cognitive support
- Energy
- Neuroprotection
How it works
- Stimulates PGC-1alpha for new mitochondria
- Potent antioxidant (redox cycling)
- Nerve growth factor support
- Protects neurons from oxidative stress
Dosage
- Typical range
- 10-20mg daily
- Timing
- Morning
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Mitochondrial support, cognitive enhancement
Forms
- Capsule
- Lozenge
Safety
Common side effects
- Well tolerated
- Headache rare
- Insomnia if taken late
Contraindications
- None established
Products containing PQQ (Pyrroloquinoline Quinone)
Top-scoring supplements in our catalog that list PQQ (Pyrroloquinoline Quinone) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Unique mitochondrial biogenesis support, growing research
Grade B: Some human trials support key claims; further confirmation needed.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.