Nootropic

Sulbutiamine

Also known as: Arcalion

Evidence

Synthetic thiamine derivative crossing BBB. Reduces mental fatigue and may support mood.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Mental fatigue
Mood
Memory
Motivation

How it works

Crosses BBB unlike thiamine
Modulates dopamine transmission
Reduces asthenia (fatigue)

Dosage

Typical range: 400-600 mg daily
Timing: Morning
With food: Optional
Duration: Tolerance can develop
Special populations: Mental fatigue, asthenia

Forms

Capsules
Powder

Safety

Common side effects

Headache
Insomnia
Irritability

Contraindications

None

Evidence notes

Fat-soluble thiamine with CNS effects

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.