Nootropic

Sulbutiamine

Also known as: Arcalion

Evidence

Synthetic thiamine derivative crossing BBB. Reduces mental fatigue and may support mood.

Primary uses

Mental fatigue
Mood
Memory
Motivation

How it works

Crosses BBB unlike thiamine
Modulates dopamine transmission
Reduces asthenia (fatigue)

Dosage

Typical range: 400-600 mg daily
Timing: Morning
With food: Optional
Duration: Tolerance can develop
Special populations: Mental fatigue, asthenia

Forms

Capsules
Powder

Safety

Common side effects

Headache
Insomnia
Irritability

Contraindications

None

Evidence notes

Fat-soluble thiamine with CNS effects

Grade B: Some human trials support key claims; further confirmation needed.

Related in Nootropic

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.