Nootropic

Polygala tenuifolia

Also known as: Yuan Zhi, Chinese senega, Polygala tenuifolia 20:1 Extract, Thin-leaf Milkwort

Evidence

A traditional Chinese herb used for centuries to support memory, cognitive clarity, and emotional balance; the 20:1 extract represents a concentrated form standardized to preserve bioactive constituents. Modern research suggests potential nootropic and anxiolytic properties, though human clinical evidence remains limited.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Memory
Mood
BDNF support
Anti-anxiety
Memory and learning enhancement
Cognitive clarity and focus
Mood and emotional stability
Sleep quality
Stress and anxiety reduction

How it works

May increase BDNF
Anti-inflammatory in brain
Traditional memory tonic

Dosage

Typical range: 100-300 mg extract daily
Timing: Any time
With food: Optional
Duration: Weeks for effects
Special populations: Memory, mild anxiety

Forms

Root extract
20:1 dry extract· 70/100
Raw root powder· 70/100
Liquid extract· 70/100
Standardized extracts (variable standards)· 70/100

Safety

Common side effects

GI upset

Contraindications

None known

Evidence notes

Traditional cognitive herb

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.