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Nootropic

Saffron Extract

Also known as: Crocus sativus, Kesar, Saffron, Za'faran

A
Evidence

A standardized saffron stigma extract containing 7.5% crocins and 1.0% safranals, the primary active compounds associated with mood, vision, and antioxidant support. One of the most expensive spices with a growing clinical research base.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Depression
  • Mood
  • Memory
  • PMS
  • Mood and emotional well-being support
  • Eye health and vision
  • Antioxidant support
  • Cognitive function

How it works

  • Serotonin reuptake inhibition
  • NMDA modulation
  • Antioxidant carotenoids

Dosage

Typical range
15-30 mg standardized extract
Timing
Any time
With food
Optional
Duration
4-6 weeks for mood effects
Special populations
Mild depression, PMS

Forms

  • Affron extract
  • Stigma extract
  • Stigma extract, standardized to 7.5% crocins and 1.0% safranals· 70/100

Safety

Common side effects

  • Dry mouth
  • Headache
  • GI upset

Contraindications

  • Bipolar (may trigger mania)

Evidence notes

Well-studied for depression

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.