Nootropic

Saffron Extract

Also known as: Crocus sativus, Kesar, Saffron, Za'faran

Evidence

A standardized saffron stigma extract containing 7.5% crocins and 1.0% safranals, the primary active compounds associated with mood, vision, and antioxidant support. One of the most expensive spices with a growing clinical research base.

Primary uses

Depression
Mood
Memory
PMS
Mood and emotional well-being support
Eye health and vision
Antioxidant support
Cognitive function

How it works

Serotonin reuptake inhibition
NMDA modulation
Antioxidant carotenoids

Dosage

Typical range: 15-30 mg standardized extract
Timing: Any time
With food: Optional
Duration: 4-6 weeks for mood effects
Special populations: Mild depression, PMS

Forms

Affron extract
Stigma extract
Stigma extract, standardized to 7.5% crocins and 1.0% safranals· 70/100

Safety

Common side effects

Dry mouth
Headache
GI upset

Contraindications

Bipolar (may trigger mania)

Evidence notes

Well-studied for depression

Grade A: Multiple well-designed human trials support the main claims.

Related in Nootropic

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.